Jackson-Pease, Heather, 2022-2023

Heather
Jackson-Pease

Principal Investigator: Matthew Porteus, MD PhD
Stanford Institute for Stem Cell Biology and Regenerative Medicine

ENGINEERING ENDOTHELIAL CELLS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

Due to the theory that pulmonary arterial hypertension is a disease that is associated with damage to the function of the endothelium, overexpression of key enzymes and growth factors that give rise to a healthy endothelium, may prove to be a good method of treatment. Editing and engrafting endothelial cells onto stents and implanting them into arteries has shown to be a promising approach to treating pulmonary hypotension. Here, we show that using an AAV mediated approach to editing endothelial cells increases the population of GFP+ endothelial cells.